most, hairy.
The mice grew new follicles - and new hair (white) - after injury healed
Mayumi Ito / University of Pennsylvania
Desperate. bald should not try at home, but the researchers found that mice will regrow hair, not only the skin, after a flesh wound. The discovery precipitated the dogma that adult mammals can not produce new hair follicles, and suggests ways to improve skin grafts and reverse hair loss.
Steeped in the dermis of the skin, hair follicles packets dead cells together at its base and sends them to germinate as hair. Researchers have long believed that a mammal is born with a full set of follicles, leading to an irreversible decline in the dark with all lost or damaged. It was fifty years ago, researchers noticed regrowth of injured skin of mice, rabbits and humans, but the work "was somewhat ignored," says dermatologist George Cotsarelis survey of Pennsylvania School of Medicine of the University in Philadelphia .
recently, while studying how stem cells in the skin to help heal wounds, Cotsarelis and colleagues noticed the same phenomenon. Comb for an answer, the team removed skin patches mouse and let the injury heal naturally Hair sprouted in central healed patches of skin the team then scored bulges hair -.. the pocket of a follicle where stem cells reside - in healthy skin near the wound. Although the bulges have cells that moved and helped to close the wound, they make new follicles.
further experiments have shown that, rather than developing follicular cells strains, new follicles were from stem cells of the epidermis. "They have grown from cells that are not [normally] make hair follicles," Cotsarelis said. "They had to be reprogrammed" A key player in this reprogramming appears to be the Wnt protein, which plays many roles in the development and healing of wounds. More Wnt mouse occurs naturally, more hair grew And. the injured area should be important to stimulate hair growth, reports the team tomorrow in nature. Follica, a Cotsarelis co-founded company, is exploring how to apply the finding of reverse hair loss.
"Regenerate a new body from scratch is quite remarkable," said Bruce Morgan, a molecular geneticist at Harvard Medical School in Boston. He noted that the results can lead to better skin grafts; current grafting techniques do not allow the growth of follicles and glands necessary for the skin to maintain. He is not surprised that there seems to be a cross, with stem cells of the skin resulting in follicles, while the follicles are sending in cells to help close the wound. "When there is an injury, any worldwide locations "
related site
- An introduction to hair
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