Etiquette Resveratrol -. as well as alcohol -. may protect against heart disease
Despite a diet full of fat chock- artery-clogging, people living in France are much less prone to heart disease than Americans or the British. Scientists now say they have identified the molecular basis of the French anomaly -. A compound found in red wine that may thwart heart disease and cancer
The French passion for fat laden foods such as butter, cheese, rich sauces and pâté made blanch US cardiologists. Yet the French death rate from cardiovascular disease was 50% lower than America, and 75% less than Britain's - a disparity that has become known as the French paradox. Deaths from breast cancer are also less frequent in France. Many scientists suspect that wine, another staple of French meals can be counteract the adverse effects of a fatty diet. There are nine years, a report 60 Minutes explore this possibility was bubbling winemakers; he uncorked a 40% increase in wine sales in the US.
But what myriad components of wine may protect? Some scientists alcohol to credit himself with much of the effect, but the cancer biologists Minnie Holmes-McNary and Baldwin Albert of the University of North Carolina, Chapel Hill, emphasized that beer drinkers do not seem benefit. That's why they focused on resveratrol, an antioxidant compound found in red wine that previous studies have indicated may suppress inflammation and cancer formation. They dosed human cells and in rat growth in culture with resveratrol and measured the effect on nuclear factor kappa B (NF k B), a known versatile protein to promote growth and cancer inflammation - which is thought to be important in atherosclerosis.
As the scientists report in the July issue of Cancer Research , resveratrol prevented the release of NF- k B from storage sites within of the cell. As a bonus, it stimulated the cancer cells to kill themselves. Since resveratrol is abundant in purple grape juice, raspberries and peanuts, teetotalers can enjoy the benefits of this compound so, Holmes-McNary said.
Eric Rimm, an epidemiologist at the Harvard School of Public Health, said points to possible new treatments for heart disease study. However, he says that there is "overwhelming evidence" that alcohol itself protects the hearts of wine lovers. For him, the French paradox is not a great mystery. Rimm said: "Hey, there is ethanol, stupid!"
Related Sites
The Baldwin Lab
Wine and Heart Disease - Review by Andrew Waterhouse of the University of California, Davis
American Heart Association statement on alcohol and heart disease
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