through the low, please. Omega-3 fatty acids, a main component of fish oil, are known to be powerful anti-inflammatory agents. Now researchers think they know how the acids block this immune response. They also found that omega-3 can help fight against diabetes in obese mice, pointing the way to potential therapies in humans.
To understand how omega-3s curb inflammation, Jerrold Olefsky, an endocrinologist at the University of California, San Diego, and colleagues trawling the data on a family of proteins called G protein-coupled receptors , which can bind to a number of different fatty acids. One of these receptor-GPR0- "jumped right out," said Olefsky. The group Olefsky found on immune cells involved in inflammation, as well as in mature fat cells, and they noted that it seemed bind to omega-3.
to confirm the link, the team doused mouse immune cells containing GPR0-with omega-3 fatty acids. This "closed nearly all inflammatory pathways," said Olefsky. "It was a very powerful effect."
The researchers also genetically mice to lack the GPR0 receptor changed. They then fed the mutant mice and normal mice a diet high in fat. both groups became obese and developed a form of mouse diabetes scientists have long suspected a link between inflammation and diabetes linked to obesity. and indeed, when the team completed the regime Olefsky fatty food with a heavy portion of omega-3 fatty acids enough to double the concentration of omega-3 fatty acids in normal mice mouse blood experienced a reduction of their diabetic symptoms. the rodents remained obese but they found a certain sensitivity to insulin, which means they do not need as much insulin to take up glucose and burn it to produce energy. in fact, the supplemented diet worked too although the fight against insulin resistance that the drug against the common Avandia diabetes, the team reports in the September 3 issue of cell . The mutant mice remained diabetic regardless of how much they consume omega-3, stressing the importance of the GPR0 receptor.
"The results are preliminary but exciting," says Nader Moniri, a pharmacologist at Mercer University in Atlanta. "For the first time, we will link inflammation to GPR0." Moniri stresses that GPR0 receptor also appears in the intestinal cells, where it appears to regulate a hormone that pushes the pancreas to release insulin. this means there are two ways in which GPR0 could influence diabetes, making it a nice target drug, he said.
Olefsky suggests that the GPR0 receptor is the primary means by which the inflammation of omega-3 control, but recognizes that there may be other mechanisms. for example, digestion breaks omega-3 fatty acids shorter fatty acids. Some data suggest that they may also influence inflammation, but not through GPR0, he notes.
Olefsky will also not go as far as to recommend that people take fish oil pills to ward off inflammation and diabetes. "We have never worked with people about it," he said, "so we have no idea how omega-3 fatty acids much a person would have to take."
0 Komentar