The scientists found that immune systems ravaged by AIDS patients can bounce back from the state of the art drug treatment kept the HIV at bay for a year. But the findings, reported in tomorrow's issue of Science * it clear that the complete reconstruction of a devastated immune system of HIV is a challenge, especially given the limitations of treatment available today.
The new HIV treatments are ward off illness and death in thousands of people. To get a better idea of how prices of the immune system after therapy immunologist Brigitte Autran of H ™ pital Pitié Salpétrire in Paris and colleagues analyzed white blood cells or T cells, which have a receptor known as CD4 name on their surfaces. HIV selectively infects the cells of the immune system, leading to their destruction. In time, people with HIV are left with so few CD4 their immune system can not repel even the wimpiest bacteria, viruses or fungi.
A major benefit widely observed in people receiving powerful new treatments is bouncing CD4 dramatically. Yet overall, but most healthy people infected CD4 do not return to normal levels. Moreover, it is unclear whether patients really regenerate CD4 or simply "redistribute" those who were sequestered in the lymph nodes and other tissues. This, in turn, determines how the effectiveness of the "new" are CD4 fight against infections.
The group analyzed the CD4 Autran who returned in eight adults taking a powerful combination of three anti-HIV drugs. After 1 year, the drugs had pushed the virus and CD4 cells had jumped twice. But because all the CD4 are not created equal, the researchers used other markers on the surfaces of these cells in order to classify them as belonging to the "memory" or subset "naive". A memory cell only responds to invaders it has seen before, while the naive cells can initiate an immune response - and create memory cells - against newcomers. In the first 4 months of treatment, the group found, CD4 return were mostly of the memory cells. But after this initial phase, the naive population rose sharply, indicating that the new cells were generated. - And by providing a "directory" more diverse CD4 capable of responding to new invaders
The study is "the best that the analysis of T cells back after a triple drug therapy that I saw "says immunologist Donald Mosier of the Scripps research Institute in la Jolla, California. However, he warns, the chances are "slim to none" that HIV drugs will eventually allow the immune system to replenish completely with fully functional CD4, both because of the limitations of medicine and the ability of the immune system to settle. "I would be really surprised if you can keep doing this year after year," he said. Autran has hope, however. "I'm very optimistic that if we could reduce the level of virus replication enough, we could discuss this, "she said.
* For details, Science Online subscribers can connect the full report.
0 Komentar