In a coda to a major case of alleged research misconduct at Duke University Durham, North Carolina, in the late 00s, newly revealed documents suggest that Duke officials have dismissed concerns of a medical student on the researcher working on cancer Anil Potti.
Potti came under surveillance for problems with data in several papers that reported on the use of genetic signatures of the tumor to affect cancer patients with different chemotherapy regimens in clinical trials. Although external biostatistician had raised questions about the work of Potti, Duke canceled the trial and put Potti on administrative leave after only Letter cancer , a DC-based newsletter in Washington , stressed false information in his resume. Potti left Duke in 2010. Many Potti papers have since been retracted, and an Institute of Medicine (IOM) 2012 report found problems with the handling of the Duke case, and the field of cancer research "omics".
Duke officials said the IOM panel that there was never an informant in the case Potti, according to Letter cancer . But this claim is contradicted by the documents that the newsletter obtained as part of a lawsuit against Duke by patients in clinical trials. According Jan. 9 issue of the newsletter, the trials began in 08, a medical student in the lab of Potti named Bradford Perez raised concerns about statistical analyzes in the papers of Potti in emails and a memo to Duke officials. Perez noted that he himself had removed as co-author of several papers Potti and asked to change the laboratories at the risk of damaging his career. "By raising these concerns, I have nothing to gain and much to lose," he wrote in the memo.
mentor, geneticist Joseph Nevins of cancer Potti, pleaded with Perez not to send a letter about his concerns to the Howard Hughes medical Institute, which supported because it would trigger an investigation at Duke, according to a filing cited in court documents. Perez is now a resident at Duke.
Duke officials said the Letter cancer that the university "argued Dr. Perez as he raised his concerns in 08 and the more "and Duke," acknowledged there years ago many aspects of this situation could have been handled differently had there been more complete information on time decisions were made. "
0 Komentar