human DNA isolated.
National Institutes of Health
The rules of a $ 10 million jump in genome sequencing just a little easier and a little more difficult. Archon Genomics X PRIZE presented by MEDCO was created in 06 by the X PRIZE Foundation in Playa Vista, California, to promote the rapid development of cheap, accurate sequencing of the human genome for medical purposes. At the time, the goal was to decipher 100 human genomes in 10 days for an all-inclusive cost of less than $ 10,000 piece. Although eight organizations finally signed for the challenge, no fact tried to do the sequencing.
Since then, sequencing costs have fallen, putting the human genome in the range of $ 10,000. But respect the 10-day limit has remained an impossible deadline. And the foundation and the sequencing community has never really worked out how to judge the price. Consequently, they decided to start over.
Today in Nature Genetics and a New York City press conference, Larry Grant Campany Kedes and the X PRIZE Foundation put the revised challenge, which includes a period less tight and other changes.
Under the new rules, from January 3, 2013, the gun goes off on a race to sequence the genomes of 100 centenarians who are identified by the foundation. The deadline is 3 February, not January 13, but winning the full price will require that each genome costs no more than $ 1,000. Entries must also meet strict requirements for accuracy, 1 error per million bases, and completeness 98%.
"I think [that price] can achieve," said Granger Sutton, a biologist for calculating the J. Craig Venter Institute in Rockville, Maryland. "But also beat all other standards will be very difficult."
If no one succeeds, judges will award any prize in different categories as long as the entries meet certain minimum standards. If more than one group meets the requirements of the grand prize, the winner will be the one who finishes first.
The objective is to show that it is possible to sequence the human genome accurately at low cost, with the hope that the collection of this data will eventually become routine in the clinic. By choosing healthy people over 100 and making that data available to scientists, the organizers also hope the cooperation will lead to new perspectives on longevity and healthy aging, says Kedes.
The organizers and their advisers have also spent the last 2 years to come with a cost effective way to judge the sequenced genomes, inviting input from the community. They will not be comparing genomes subject to each other; instead when the contest is going on, they have already sequenced parts of 25 genomes with multiple technologies, using a variety of techniques to ensure that each base this set is correct. They will then compare quotes these corrected sequences. Accounts will also go on the costs to ensure that every penny was accounted for, said Kedes. But he still works with sequencers come with the final rules.
The foundation will be in contact with the original eight participants, but Kedes predicted that some leave because they are companies that once focused on DNA sequencing, but today changed the priorities. Other organizations who originally said they are not interested, as Illumina, now could be serious contenders, said Sutton. Since the contest will be how long, "most likely to compete are those that can change that [technology] they have," said Sutton. Again, "you can never be sure of what exists."
0 Komentar