The National University of Singapore (NUS) today announced that it has found no evidence of research misconduct by Yoshiaki Ito, a high-profile cancer researcher accused of manufacturing data. However, the conclusion does not resolve the underlying dispute and long-running science-whether a gene known as RUNX3 is a tumor suppressor.
A group led by Yoram Groner of the Weizmann Institute of Science in Rehovot, Israel, published a paper in Development Mechanism in 01, in part concluded that RUNX3 could be found in the gastrointestinal tract. A year later, a team led by Ito and colleagues according to Cell paper RUNX3 suppresses gastric cancer. since the two discussed their respective positions at conferences and in publications. Groner last document claiming refute allegations of Ito appeared online Aug. 8 in EMBO Molecular Medicine . But he went further, filing a formal complaint with the university that the experimental results of Ito "could not be achieved in the first place," he said Science . In accordance with standard procedures, NUS has launched an investigation that led to today's statement:
The September 20, 2011, NUS began looking into a complaint that had received wide publicity in the lay and scientific media suggesting possible research misconduct by Professor Yoshiaki Ito. The complaint received by NUS linked to the assertion that some Prof Ito data published in 02 can not be reproduced. We have now completed our review in accordance with our research integrity procedures, and find no evidence of misconduct in research by Professor Ito. NUS notes that this issue was the subject of a long and open scientific disagreement. honest differences in interpretations or judgments of data are best addressed by further research and scholarship.
"I am very heartened that NUS rid me of research misconduct," Ito wrote in a statement. The argument on RUNX3 should continue. Ito added that the expression of RUNX3 in the human gastrointestinal tract, as the group reported, was confirmed independently by others. "All personal decisions regarding NUS Dr. Ito's not my business, "Groner wrote in an email. But it fell on its scientific pretensions." my only concern in this case is the removal of the research literature misinformation and misleading published in 02 cell paper (that of Ito group), "he writes.
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