The world of research on stem cells has been set on its ear 29 January when Japanese and American scientists reported a surprisingly simple way to generate stem cells that can theoretically develop in all cells of a body. But the anonymous bloggers and some experts have spotted possible manipulation of images in newspapers. The establishment of the principal researcher studies.
Haruko Obokata Developmental Biology of RIKEN Center (CDB) in Kobe, Japan, and colleagues from other institutions in Japan and Harvard Medical School in Boston reported that simply submit blood cells from newborn mice to a moderately acidic environment for 25 minutes and then refine culture conditions could generate pluripotent stem cells capable of developing into almost all types of cells of an organism. They described what they called the acquisition of pluripotency (STAP) cells stimulus triggered in a research paper and a research letter published online in Nature on 29 January.
Just a week later, anonymous bloggers on PubPeer website postpublication a discussion forum of scientific results, began to notice anomalies in the picture 1i in the research article. In some eyes, it appears that the central channel of a blot image was spliced into. On February 13, contributors PubPeer zeroed in the letter of research, arguing that a portion of Figure 1b, showing the placenta of a chimera STAP, may have been rotated and reused in Figure 2g.
in the emails that responded to questions posed by science Insider, the public relations office at the headquarters of RIKEN in Wako, near Tokyo, wrote that they were the site of the current but launched its investigation on February 13 in response to a notification received from an outside expert. The investigation team includes both RIKEN and outside scientists. RIKEN could not say when the investigation is complete, leads, or if it only focuses on the images reported on PubPeer.
A public relations officer at the CBD said Obokata and colleagues directed all queries to RIKEN seat.
On February 13, a Japanese blog pointed to possible manipulation of images in a 2011 document tissue engineering by Obokata and others. Furthermore, on 14 February, a Japanese blogger published a note stating that "the problems of some images of the research article could be the result of image compression noise."
the RIKEN responsible for public relations wrote that their investigation only covers two Nature papers.
Both documents were revolutionary because they have put forward a method for generating stem cells much simpler than any previously reported, a development that could advance regenerative medicine, in which scientists try develop replacement tissues as a treatment for diseases and injuries.
The image problems could not say the reported results are not valid.
"for the moment, we think the research results published in Nature are sound," the public relations office wrote.
other laboratories already trying to reproduce the work, and some have posted their experiences on a blog stem cells. Nobody has said they have successfully reprogrammed cells, but most have not used the same cells used Obokata
* updated February 17, 15 hours :. a sentence referring to a second blog post in Japan can image compression discussion has been revised following a clarification of its English translation.
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