In a flash. RAPTOR (left) and KAIT saw a gamma ray burst less than 2 minutes after satellite alert.
New evidence shows that hormone replacement therapy (HRT) does not improve the quality of life for postmenopausal women. According to Deborah Grady, an epidemiologist at the University of California, San Francisco, the message is clear for women without menopausal symptoms:
The "There is no role for hormone therapy." first bad news for HRT came in July 02 when the Initiative on women's health (WHI) 16,608 patients showed that HRT - Wyeth Prempro, in particular - increased the risk of breast cancer, heart attack and stroke ( science NOW, July 9, 02). The new analysis of WHI, published online March 17 by the New England Journal of Medicine (NEJM) , shows that women taking Prempro had little to no benefit compared to placebo in the fight against symptoms such as hot flashes, vaginal dryness, and forgetfulness. The finding is surprising and ironic, given that many women continued HRT specifically to improve the quality of life in the months since the first WHI results were announced.
The new study, led by Jennifer Hays of Baylor College of Medicine in Houston, found no significant improvement in vitality, mental health, depression or sexual satisfaction. However, a subgroup of moderate to severe reporting hot flashes, night sweats and sleep disorders had a "small advantage" to relieve sleep disorders. The study has its limitations. Most women were asymptomatic when they entered the office, and some women with severe symptoms probably did not sign for fear of being given a placebo. Consequently, the study may have little benefit for women with symptoms underestimated.
The risks of HRT However, since even women with severe symptoms should consider alternatives, Grady wrote in an editorial that will be published with the report in the May 8 issue of NEJM . For those who must take hormones, clinicians should try at least once every six months to reduce the dose, and then stop.
Some questions remain.
Sites Some researchers have questioned whether the results of the WHI apply to all HRT combinations, or lower doses, or short-term or intermittent use, could limit or eliminate the disadvantages. on
Hays website
Initiative for Women's Health
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