pills Fistful. A man holds a cocktail of drugs against HIV
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Loads of studies have shown that effective anti-drug combinations HIV introduced in 1996 can potently suppress the AIDS virus, ward off illness and death. Now a report published in July 26 issue of The Lancet offers the most comprehensive analysis yet of the impact of this new era of treatment on life expectancy. Examining the medical history of more than 40,000 people treated in the United States, Europe and Canada, researchers found that 20 who began treatment between 1996 and 05 can expect to live until age 63. untreated HIV in developed countries usually causes death within 12 years.
the leader of the study, demographer Robert Hogg of the British Columbia Centre for Excellence in HIV / AIDS in Vancouver, Canada, said the analysis provides strong evidence that, where treatment is available HIV is now a chronic disease. "An infected pregnant woman 20 years beginning the treatment will see the baby grow and could even see the grandchildren," says Hogg. "It really changes the paradigm."
The first antiretroviral drugs came on the market in 1987 added a year or two of life, and their use rapidly leads to drug resistance. The new study takes a moment where powerful drug cocktails became available. Overall, the team found that the life expectancy for a 20 year old increased steadily between 1996 and 05 from 56.1 to 69.4 years. This indicates that the anti-HIV drugs used in combination therapy improved during the decade, with more power and less side effects, says Hogg. They have also become easier to take :. Rather than swallow, say, a few dozen pills every day at three different times as required in 06, combinations of several drugs now exist that allow a daily administration
Frank Palella, a specialist in diseases infectious at Northwestern University in Chicago, Illinois, said a "nuance" of the new analysis is that "life expectancy has increased dramatically in treated appropriately people." HIV cripples the immune system by destroying white blood cells called CD4, and the Lancet paper shows that people who started treatment with lower CD4 cells was much darker. more specifically, 20 years old less than 100 CD4 had a life expectancy of 32.4 years and older compared to 50.4 years if the same person started treatment with more than 0 CD4.
the study deals no controversial question of when to start treatment, but Palella said it reinforces the growing consensus that high levels of HIV lead to systemic inflammation which can damage the heart, liver and other organs, shortens life - even in the absence of opportunistic infections associated with AIDS runaway.
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