A new study in India shows that people newly infected experience fever of the AIDS virus, joint pain and night sweats weeks before conventional blood tests can detect infection. The study, published in the tomorrow of Journal of the American Medical Association , points to two other early denunciations to possible HIV infection :. genital and sexual recent ulcerations not protected with prostitutes
the global AIDS epidemic rages more furiously in India than in any other country, with as many as 5 million people infected, according to the World Health Organization Health. A team of three organizations - the National Institute of Allergy and Infectious Diseases (NIAID), the School of Hygiene at Johns Hopkins University and Public Health, and the National Institute for Research on AIDS in Pune India - studied 3874 people in India to identify HIV in the early warning signs and get a close examination of behaviors that spread the disease.
patients were tested for p24 antigen, an HIV core protein in a test that is much more expensive than standard antibody tests. According to Thomas Quinn laboratory immunoregulatory NIAID is the lead author of the study, the p24 antigen can be detected in blood infected by HIV 2 to 3 weeks after infection - several weeks before HIV antibodies first appear. "With the p24-antigen testing, we can identify HIV infections much sooner after they occur and get a more accurate picture of the risk factors and symptoms of acute HIV infection," he said .
the p24 positive patients had regularly from a collection of symptoms - fever, night sweats, joint pain and other symptoms, such as enlarged lymph nodes, oral thrush, diarrhea. and rash, which previous studies had linked to acute infection were rare in people with p24. Two other features stand out in the p24 positive patients. They were 50% more likely than uninfected people to have had of unprotected sex with a prostitute, and they were almost twice as likely to have an active genital ulcer
research provides a valuable look at the first signs of HIV infection, said Rod Hoff , an epidemiologist in the Division of AIDS at NIAID. Early detection means regimens may start earlier. Hoff cautions, however, that the symptoms observed in study participants could be nonrepresentative, because studies have been done on a small group of people seeking treatment for sexually transmitted diseases and subtype HIV can be unique.
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