N EW O RLEANS - As for exercise? This may be the key to all the good your workout makes you. A neuroscientist announced today at the annual meeting of the Society for Neuroscience here that rats compelled to exercise a weakened immune system suffered, while those who exercised the same amount unconstrained showed healthy immune responses.
The exercise clearly has direct effects on health, such as building muscle mass and improve cardiovascular health, but research has also shown that it can have indirect benefits, such that strengthening the immune system and reduce stress-related illness. Furthermore, numerous animal studies on exercise have come to the opposite conclusion, suggesting that exercise suppresses the immune system. Monika Fleshner at the University of Colorado, Boulder, suspects that the blame may not lie with the drive itself, but the scheme.
Fleshner studied two groups of male rats. Those groups were forced to run on a treadmill once a day. The others had exercise wheels in their cages and were allowed to run whenever they wanted. At the beginning of the 8-week study, Fleshner challenged the immune systems of rats with a foreign protein, and by the end of the study, they were reminded of the same protein. Fleshner sampled rats antibodies made in response to the protein, and also verified the spleens of animals and lymph nodes for reactive immune cells.
Both groups exercised comparable amounts of time during the study, Fleshner said, and they lost similar amounts of weight. But the animals were forced to exercise "showed classic signs of chronic stress," including deleted antibody responses, as well as enlarged adrenal glands. The rats that were forced to exercise had immune responses 20% to 30% lower than those of control animals that did not exercise at all, while the immune responses of animals that exercised by choice have been improved. the forced exercise is probably causing stress animals because they feel out of control, said Fleshner.
the study could have important clinical implications, said researcher exercise Judy Cameron of the University of Pittsburgh, as he points out that "the perception of what exercise is like can have health effects. "Indeed, says Fleshner, military cadets, who are forced into the practice of training and punishment, have been shown to be immunocompromised, though it was not related to the exercise. The study may encourage members to reconsider the way it uses the exercise, said Fleshner. Similarly, heart doctors might want to consider that their patients benefit when designing exercise regimes.
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