The largest imaging study ever of Health will soon offer researchers a peek inside the body British. The UK Biobank, a biological repository nonprofit Stockport, today announced its intention to scan 100,000 bodies over the next 6-8 years. The shots, taken with magnetic resonance imaging (MRI) and other conventional techniques, will be connected to various data on health and lifestyle, enabling scientists to improve understanding and disease diagnoses such as cancer, dementia, arthritis and osteoporosis and coronary heart disease.
Biobank was created in 06 by the Medical Research Council (MRC) and the Wellcome Trust. The goal was to create a resource for health researchers by collecting data such relevant health such as diet, physical activity, lifestyle, and cognitive-function as well as blood samples and DNA from half a million people in the UK. For analysis of health outcomes, these data are linked to hospital records, death records, and now individuals Health GPs.
So far Biobank has the DNA of 150,000 people and expects to have the DNA of another 350,000 at the end of the year. They have a physical activity of 100,000, taken from a watchlike monitor up to 7 days. Blood samples were analyzed for hormones, glucose, lipid markers and other aspects.
A pilot project to add biomedical images has recently been supplemented by analysis of 8,000 people. Scaling up to 100,000 will cost £ 43 million, to be paid by the MRC and the Wellcome Trust
Imaging include :.
- Heart -Bedroom diameter; the volume of blood flow; thickness of the heart wall; thoracic aorta size, shape and the stiffness
- brain -Structure and function; gray matter volume; Mapping of major brain connections
- Fat -Distribution through the body; measures of abdominal fat volume, including the liver and pancreas
- Bones -X-ray measurements of bone density; arthritis in the spine, hip and knee; vertebral fractures
- Arteries Ultrasound evaluation of the carotid arteries, which run on either side of the neck to the brain
There are many potential gains. Because the analysis will be taken by the participants who are healthy or sick, researchers might be able to identify changes before symptoms appear; it may one day improve diagnostics. They hope to identify new risk factors and perhaps improve methods of analysis themselves.
The data will be accessible to health professionals who register with Biobank. Existing data are being studied by about 2700 researchers from the UK and other countries, both in academia and industry.
"This set of advanced medical image data will be unprecedented in synergy with biological information from other studies," said Roderic Pettigrew, director of the National Institute of Biomedical Imaging and Bioengineering in Bethesda , Md. "It will reveal biomarkers that we can not get any other way and give us a better understanding of how to prevent, detect and treat the disease."
0 Komentar