Mystery revealed. The knee of a patient with an artery in the leg calcified.
NIH
A popular program that provides patients with mysterious illnesses to the National Institutes of Health (NIH) campus in Bethesda, Maryland, so the experts can try identify the cause of their disease develops in universities.
The 4-year-old NIH Undiagnosed Diseases Program (UDP) evaluated 500 patients who come to the Clinical Center of the NIH for clinical and genetic testing. About 10%, or 50 patients were fully diagnosed with a genetic disease and about 30% have a partial diagnosis, says Director William Gahl UDP National Institute for Research on the human genome. Often they have "rare disease" incredibly with only a few dozen cases in the world, said Gahl. UDP found two diseases that are new to science-a neurological disorder and a condition that causes arteries calcify. Another 15-20 cases can be genetic disorders news, said Gahl.
UDP now sees over 150 patients a year and has a budget of $ 3.5 million. The program, a media favorite, received thousands of inquiries. There is one year, the NIH has temporarily stopped accepting applications for catching up.
NIH could expand the intramural program, but he wanted to "let others engage in this" and to create centers which would be located near the patient says Gahl. NIH plans to finance five or six extramural centers at $ 145 million over 7 years. Researchers will be trained to UDP methods for screening patients, clinical studies and genetic tests, which may include sequencing the DNA encoding the protein of the patient's family. Each center will see about 50 patients a year, which, combined with the Bethesda patients will bring the total to 450.
The expansion comes from the NIH Common Fund, a $ 557 million program for cross-initiatives turns on a little money each year than the wind projects down or move to the NIH institutes. Another new launch Common Fund initiative in 2013 will focus on the RNA molecules that cells secrete to communicate with each other. The extracellular RNA Communication program will receive $ 130 million over 5 years.
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