Headache for moms grass. painkillers like aspirin can increase the risk of miscarriage.
women trying to conceive should not take two aspirin and call your doctor in the morning, according to a new study. It shows that aspirin and ibuprofen, but not acetaminophen, taken at the time of the design almost double the risk of miscarriage. The findings may change the way doctors recommend over-the-counter painkillers to pregnant women.
About 15% of pregnancies end in miscarriage, and doctors know little about the factors that put women at increased risk. A study last year suggested a link between a class of painkillers called nonsteroidal anti-inflammatory drugs (NSAIDs) and miscarriages. NSAIDs, which include common painkillers such as ibuprofen and aspirin, reduce pain by purging prostaglandins, which fertilized eggs must be planted in the womb.
To test whether NSAIDs rattle pregnancies, a team of researchers led by epidemiologist reproductive-Kun Li of the Research Institute of the Kaiser Foundation in Oakland, California, surveyed 1055 women who conceived in the 40 previous days. They requested the use of pain-around time, women trying to get pregnant and have followed pregnancies in women who have succeeded. The researchers took into account activities such as drinking coffee or hot-tubbing and excluded women at risk of miscarriage in the absence of treatment, such as women who reported cramps.
The risk of miscarriage is 80% higher than normal for women who took aspirin or ibuprofen (the active ingredient in Advil) regularly for more than a week, the team reports in the issue of British Medical Journal August 16 Acetaminophen (the active ingredient in Tylenol) has no effect on pregnancies at all. The risk jumped dramatically if women took the drugs in a week of design: Five times the number of women taking one of two NSAIDs had miscarriages, compared with women who took nothing or have taken acetaminophen. In the end, Li said, the Federal Drug Administration will decide whether to reclassify aspirin and ibuprofen. Li noted that newer NSAIDs, COX-2 inhibitors such as Celebrex, were tested for reproduction and are not recommended for pregnant women.
Epidemiologist Gunnar Nielsen of Odder Hospital in Denmark said the study shows "almost beyond doubt" that NSAIDs, it will be harder for some women to get pregnant. "If pregnant women need analgesics during pregnancy," he suggests, "they should ask their doctor if [acetaminophen] will be enough."
Related Sites
The page of De-Kun Li at Kaiser
NSAIDs on the net
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