preserve hair. CDK2 inhibitor, when rubbed on mice heads (down) prevented hair loss caused by chemotherapy drug.
chemotherapy may save lives, but it comes with unpleasant side effects. Drugs target rapidly dividing cells, allowing them to home to tumors, but they also kill normal cells as those of the hair follicles. Although the resulting hair loss is not life threatening, it can be extremely distress for patients. Now a team reports that they can prevent hair loss caused by chemotherapy in first rats rub the skin of animals with a newly developed drug.
The new drug targets an enzyme called cyclin-dependent kinase 2 (CDK2), which results in key stage in the cycle of cell division. Many researchers in industry and academia are looking for CDK inhibitors, mainly in the hope of developing agents to block the growth of cancer cells. But William Kaelin of the Dana-Farber Cancer Institute in Boston, who is among those who do this work, emphasizes that CDK inhibitors offer two possibilities. They can be used, he said, to find "be smarter ways to kill cancer cells or smarter ways to protect normal cells."
Focusing on the latter objective, a team led by Stephen Davis Glaxo Wellcome Research and Development in the Research Triangle Park, North Carolina, has developed a powerful CDK2 inhibitor for topical application. The researchers tested the drug in both animal models. In one, the researchers transplanted human scalp hair in mice. When they applied the CDK2 inhibitor to growing hair transplants, the researchers report in the January 5 version of Science , temporarily inhibited cell division of the hair follicle. In a second model, rubbed the drug in hair newborn rats and gave them a chemotherapeutic agent. The drug prevented hair loss in half of the animals and reduced in another 20%. It was not as effective against a combination of two chemotherapy drugs, protection of only 33% of hair loss in animals. Davis also said his team did not detect any interference with the ability of chemotherapy drugs to kill cancer cells in animal tumor models.
Oncologist David Fisher of the Dana-Farber described the work to date as a "huge advance." He hypothesizes that it may also be possible to design inhibitors to protect other tissues normal which were damaged by chemotherapy drugs the lining of the intestine. - where damage causes nausea and vomiting. - It is a possibility, if a non-resorbable version can be produced
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