Early clinical trial results suggest that children healthy older under 9 will likely need two doses of vaccine against swine flu, but those between 10 and 17 can be obtained with a single stroke, US health officials announced today.
In studies sponsored by the US National Institute of Allergy and Infectious Diseases (NIAID), 8 to 10 days after receiving a dose of 15 micrograms of inactivated vaccine that contains protein of the new H1N1 virus 76% of older children had an antibody response "robust". But in children aged 3 to 9 years old, the same immune response was observed in 39% of children vaccinated, and it fell to 25% in children 6 to 35 months. Anthony Fauci, director of NIAID, said at a press conference that the vaccine behaves very much like the vaccine against seasonal influenza, which requires even a second dose in young children because their immune system less mature. "Overall, this is very good news for the vaccination program, both with regard to the supply of the vaccine and its potential efficacy," said Fauci.
As explained Fauci, antibody researchers expect answers to continue to climb for 21 days, the central points of end studies. The trials, involving 0 children, found no significant difference in antibody responses to 15 micrograms or 30 micrograms of the vaccine. The percentage of people who have a strong antibody response indicates whether a second dose is needed, but no strict off cut exists, and recommendations may change if the conflicting data surface before the vaccine becomes widely available in mid-October. The results of older children closely match the initial results with the new H1N1 vaccine in adults. No studies have reported severe side effects.
A small amount of the vaccine will be available in early October for people considered at high risk of suffering from serious diseases of the new H1N1 virus, but it will be a live attenuated product. No data yet exist on the effectiveness of the vaccine against swine flu, although Jesse Goodman of the Food and Drug Administration of the United States said at the press conference that "it is likely that younger children can need a second dose. "
in what clearly pose a logistical challenge for parents and health care providers, younger children will ideally receive two doses of vaccine against seasonal influenza, spaced 21 days apart, and as two doses to swine flu. Anne Schuchat, director of the National Center for immunization and respiratory diseases at the US Centers for disease Control and Prevention, said vaccines against influenza inactivated seasonal and swine can be administered simultaneously, but there are concerns about giving the two versions of and inactivated living products simultaneously. She advised parents of young children to begin to give them the seasonal vaccine, which is widely available now. "This will be a complicated flu season," said Schuchat.
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