Add two months the production schedule of a vaccine against the virus causing the swine flu, says an advisory group to the World health organization (WHO).
It may be mid-July before the manufacturers have the "seed stock" appropriate to start making the vaccine against the new flu (H1N1), according to a report published online today from a WHO working group on vaccines met by teleconference May 14 the report shows a crude form of seed stock will probably be ready at the end of the month, but 1-2 weeks of testing in animals will be required. manufacturers typically require 1 to 2 months more to find the most dynamic strains that produce the most virus surface proteins, which are the main ingredients in a vaccine. the group has warned that too fast " could lead to vaccine into production with low growth potential strains', as happened with a strain of H5N1, the avian flu. "Using an A (H1N1) growing evil could reduce the global supply of a vaccine (H1N1)," the group warned.
On May 1, Marie-Paule Kieny, Director wHO's initiative for vaccine research, predicted that the seed stock would be ready "in mid or late May." Kieny, who spoke at a press conference, said "the reality is that from the time the potentially pandemic virus is identified, it takes between 4 to 6 months to have the first doses of vaccine out of the factory and available to immunize people"
.work group's report does not respond when a final product will probably exist, but estimated 4.9 billion doses "could be produced. over a period of 12 months after the start of the large-scale production" the group noted that this would require using "dose formulations sparing most", which means adding boosters called adjuvants to vaccines; Vaccines against influenza approved in some countries, including the United States, do not use adjuvants. But four European countries have recently secured GlaxoSmithKline they would buy more than 100 million doses of a vaccine against it is considering making the new H1N1 strain with an adjuvant.
The working group "was premature" to start shopping -scale producing the vaccine and also stressed that although WHO is facing up to the outbreak of a phase 5 alert to phase 6, indicating a large-scale pandemic, that "does not automatically mean that the wHO recommends that manufacturers should switch to seasonal influenza a (H1N1) production."
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