Today is the birthday of Ines Mandl, an American biochemist who has conducted pioneering research on enzymes and elastic tissue that led to progress in the understanding of pulmonary emphysema.
Mandl, who was born in 1917, studied collagenase - a group of about 20 enzymes that can break down the collagen in a soluble form - and was the first to isolate and purify an enzyme. As director of obstetrics laboratories / Gynecology at the Delafield Hospital (affiliated with the University of Columbia), Mandl studied respiratory distress and emphysema in neonates and identified the role of elastin, an elastic tissue in the lungs. It showed that emphysema patients have elastin degradation, which destroyed lung tissue. Smoking, she found, elastin also damaged
In 1972, Mandl founded the magazine Connective Tissue Research
Source: Benjamin F. Shearer and .. Barbara S. Shearer, remarkable women in the physical sciences :. A biographical dictionary (Greenwood Press, 1997)
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