Five researchers studying a cellular system for fixing misfolded proteins, deep brain stimulation for the disease Parkinson's and breast cancer genetic won this prestigious Lasker award of the year for biomedical research.
The Lasker Foundation announced today that its award for basic medical research goes to Kazutoshi Mori, 56, of Kyoto University in Japan and Peter Walter, 59, of the University of California, San Francisco, for their work on what is known as the unfolded protein response. From the late 1980s, their laboratories have revealed steps in how the endoplasmic reticulum, the cell factory for secreted and membrane protein processing, trafficking of proteins whose linear amino acid sequence n has not folded into a 3D form suitable. After detection of a dangerous accumulation of unfolded proteins, endoplasmic reticulum sends a signal to the nucleus that activates genes that work to solve the problem. The research has implications for diseases such as cystic fibrosis and retinitis pigmentosa. The price of basic research Lasker often precedes a Nobel Prize in medicine; 86 Lasker winners have gone on to win a Nobel Prize.
The Lasker Award for Clinical Research was awarded to Alim-Louis Benabid, 72, Joseph Fourier University of Grenoble, France and Mahlon DeLong, 76, of Emory University in Atlanta. Also starting in the 1980s, they demonstrated in animals and people who implant surgically into the brain with a device that stimulates the subthalamic nucleus may reduce tremors and other symptoms of people with Parkinson's disease. In 02, US authorities have approved the technique for the treatment of advanced Parkinson's disease.
Mary-Claire King, 68, of the University of Washington, Seattle, won the Lasker Special Achievement Award for his discovery of BRCA1 cancer risk breast in 190 and for the development of DNA analysis techniques to identify family members. First used to help find children separated from their parents during 1976-1983 military dictatorship in Argentina, the approach has since remains and victims of natural disasters and terrorist attacks 9/11 identified human.
0 Komentar