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Summary
Dozens human enzymes incorporate or use copper, taking advantage of the willingness of metal to give or accept electrons to catalyze chemical reactions bio keys. Tumors can however be particularly dependent on the metal. Copper, for example, promotes angiogenesis, the growth of blood vessels that can feed a growing tumor, and the exhaust can keep the cancer in check. Copper also binds an enzyme which allows tumor cells metastasize and is required for signaling by BRAF mutant, which causes half of melanomas and many other cancers. "Maybe what we'll find is that the particular types of cancer are more susceptible to particular processes copper-dependent," says pharmacologist Donita Brady of Duke University in Durham, North Carolina
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