[plate history. Autopsy book with the first diagnosis of Alzheimer's disease in 1910.
Some pilferage in the basement of the University of Munich has transformed samples of brain first patient known to be correctly diagnosed with Alzheimer's disease. In this month's issue of Neurogenetics , German psychiatrists describe 0 years slides of brain tissue from a patient known as Johann F. They think it was the case that got the name of the German doctor Alois Alzheimer in medical textbooks.
Alzheimer had described a previous case of dementia, a patient called Auguste D. Last year, however, a team from the University of Frankfurt in Germany questioned whether she really suffered what is now known as Alzheimer's disease when they rediscovered his medical records. No tissue samples remained, but the autopsy report describes the hardening smaller cerebral arteries - a condition that now prevents a diagnosis of Alzheimer's disease. Later that same year, 107, Johann F. Alzheimer treaty, which also showed signs of dementia and died three years later. For decades, their records remain lost.
Now, an extensive search of the basement of the University of Munich has turned up what "beyond reasonable doubt" Johann F. brain sections, said Manuel Graeber the Max Planck Institute of psychiatry, who led the research. To verify their authenticity, Graeber had the Bavarian State Office of Criminal Investigation confirmed that the ink on the slides were more than 80 years. Book clinical autopsy, which was also found, listed the cause of death. "Alzheimer'sche Krankheit", or Alzheimer's disease
The analysis of tissue confirmed the diagnosis, but is that even this second patient did not have a typical case of the disease: Johann F. suffered from the "plate only" less common variant. It also lacks the susceptibility allele apo Alzheimer's, an established variant of apolipoprotein E gene carried by about two out of three patients.
Graeber also speculates that the case of Johann F. convinced the Alzheimer boss Emil Kraepelin to name the affliction "Alzheimer's disease" in 1910 - diagnosed by plaques in the brain - in the 8th edition his psychiatric manual. "Kraepelin and Alzheimer's were very close friends. This patient had Alzheimer staff cases, but it is very likely that he was seen by two of them," Graeber said. When Johann F. died shortly after the publication of the book, Alzheimer wrote the name of his disease in the autopsy book.
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