Ibuprofen stimulates the life span of some organisms -

Ibuprofen can banish headaches and soothe throbbing joints, but the drug may have another advantage. A new study shows that it increases longevity in laboratory organisms, raising the possibility that he does the same in people.

Researchers used to mock the idea of ​​extending the service life, but it turns out to be surprisingly Easy at least in organisms such as mice and worms. Drugs that prolong the survival of these creatures aspirin and metformin antidiabetic compound, for example, are already in many of our medicine cabinets. Several studies suggest that ibuprofen is also worth a look. Ibuprofen suppresses inflammation, which underlies many diseases associated with age and may contribute to aging itself. In addition, those taking ibuprofen for a long time have a lower risk of developing both diseases associated with aging, Alzheimer's disease and Parkinson's disease, multiple analysis found.

To ibuprofen to the test, biochemist Michael Polymenis of Texas A & M University, College Station, and colleagues gave the yeast, nematode worms and flies drug doses that are fruits comparable to what humans take. The spans all three types of organizations have increased if they received ibuprofen in life, the researchers report today PLOS Genetics . In yeast, for example, ibuprofen stretched the life of 17%, half of what researchers can produce cutting off the food supply of the cells (another approach to increase longevity). Worms survived about 10% of the drug, and flies earned about the same amount.

But it is not obvious why ibuprofen benefit these organizations. The drug comes from inflammation in people by blocking cyclooxygenase enzymes, which help synthesize inflammatory molecules promoting. Yeast and nematodes do not possess these enzymes, however, and they do not suffer from inflammation.

A clue may come from a previous study that showed the yeast medication poisons that can not make tryptophan, an amino acid, which cells need to make proteins. Polymenis and colleagues found that the tryptophan levels decreased in yeast cells exposed to ibuprofen. They also showed that the drug stimulates the destruction of a protein that allows cells to absorb tryptophan.

Ibuprofen is not a huge impact on the levels of tryptophan, although decreasing by approximately 15% to 20% in yeast. To explain how this slight decrease in tryptophan concentration promotes longevity, the researchers invoked a cons-intuitive mechanism. Many studies have shown that instead of killing the organisms, moderate amounts of stress such as intermediate doses of radiation or toxic chemicals to increased lifespan. A slight tryptophan deficiency triggered by ibuprofen might work the same way, the researchers believe. "We figure it is still a type of stress that seems to be conducive to life," says Polymenis.

"They show convincingly that ibuprofen prolongs lifespan in these model organisms" says molecular biologist Ellen Nollen the University of Groningen in the Netherlands. It is not proof of the involvement of tryptophan as persuasive, noting that the drug has changed the levels of several amino acids in the yeast cells. Ibuprofen could also promote longevity through its effects on these molecules, she said.

"There are two new good ideas here," said gerontologist Richard Miller of the University of Michigan, Ann Arbor, which is one of the participants in the US National Institute on Aging Program of intervention trials (ITP), in which researchers from three institutions are gauging if a variety of compounds modifies the increase of mouse life. one is the revelation that "some anti-inflammatory drugs that people take may have beneficial effects which are not related to inflammation, "he said. the other is the possible involvement in aging proteins that carry the amino acids in cells, which could lead researchers to new ways to wring the life.

Nollen and Miller say the study supports ibuprofen tests in mice. the ITP has evaluated a related drug, nitroflurbiprofen, and found no change in the durability. However, Miller notes, these results exclude studies on ibuprofen because both drugs are slightly different.

So far, researchers have not shown that any drug prolongs life. For people who are anxious, Miller warns against extrapolating the results of the study, especially because the side effects of the use of long-term ibuprofen can include bleeding from the stomach fatal. "I think anyone who says," Whatever works in yeast is something I want to take, 'is asking for trouble. "

What causes this pain shoulder -

What causes this shoulder pain

Each year about 14 million people seek medical treatment for shoulder problems. This includes more than 3 million visits for shoulder and sprains and strains to the upper arms.

The shoulder is capable of a wider and wider range of motion than any other joint in the human body. To remain stable, the shoulder must be anchored by its muscles, tendons and ligaments.

• The shoulder consists of three bones and three joints. It is also a complex system of muscles, tendons, ligaments and bursa bag.
• four muscles form the rotator cuff surrounding the shoulder joint. The rotator cuff provides the ability to raise the arm and reach overhead.

shoulder pain is a very common complaint with many causes.

• excessive movement of the head arm during everyday activities can cause injury.
• Tendonitis is inflammation of a tendon and is the most common of all shoulder problems. Age has a profound impact on how the body reacts to the shoulder strain or trauma. In the 30 and 40, muscles and tendons begin to undergo a structural weakening. In 40 or 45, simple tendinitis can degenerate into actual tearing of muscle tissue.
• Bursitis is inflammation of the bursa of bags which may lead to a restricted movement.
• rotator cuff injuries such as tears can result from repetitive strain progressive worsening tendinitis, and overuse or trauma.
• frozen shoulder is often caused by an injury that leads to lack of use due to pain. Arthritis may lead to frozen shoulder, causing the inability to move the arm completely.
• Arthritis is a degenerative disease caused by either wear and tear of cartilage (osteoarthritis) or an inflammation (rheumatoid arthritis) of one or more joints.
• dislocation involves tissue damage, stretching and tearing. The shoulder joint is the main joint most often dislocated. People under 20 and over 50 are most prone.
• The separation occurs when the collar bone meets the shoulder blade. Most often the damage is caused by a blow to the shoulder or by falling on an outstretched hand.

stretching and strengthening is the key to preventing shoulder problems. Furthermore, early detection is important in preventing serious injury to the shoulder.

• One study estimated the prevalence of work-related repetitive strain injuries (RSI) and found that physical activity during leisure time is associated with a decreased risk of this type of injury .
• A new study found that resistance training with free weights can help workers with severe rotator cuff injuries return to their jobs.
  

Treating wounds with RICE (rest, ice, compression and elevation)

• Rest - Reduce or .. stop using the injured area for 48 hours
• ice - Put an ice pack on the injured area for 20 minutes at a time, 4-8 times a day
• Compression -. Compressing the area with bandages, such as an elastic bandage to help stabilize the shoulder. In addition, it can help reduce swelling
• Elevation - .. Keep the injured area elevated above the level of the heart

If you still unsure of the cause of your shoulder pain, or if you do not know the specific treatment recommendations for your condition, you should call your doctor immediately

Sources :. National Institute of Arthritis and Musculoskeletal and Skin Diseases, American Academy of Orthopaedic Surgeons, Health Day, American College of Rheumatology, American Physical Therapy Association, and Washington and Shady Grove Adventist hospitals. For more information, consult your doctor.

What to expect during a stress test -

If you have experienced symptoms such as chest pain or shortness of breath, your doctor may use a stress test for whether you have a heart problem.

What is a stress test?

These tests measure how your heart works during activity or stress. It is one of the most common doctors use to diagnose and monitor many types of heart disease testing

Your doctor may order this test to see :.

• If you have heart disease
• How well the treatment, such as medicine, angioplasty or cardiac surgery, works
• Whether you are good enough health to begin an exercise or surgery program

what to expect when your stress test

stress tests take place in the your doctor's office or hospital. During the test, a doctor, nurse or technician will be with you to keep an eye on your blood pressure and heart rate and blood to monitor your symptoms

There are different types of resistance tests, including:.

• a standard stress test, which uses an electrocardiogram, or EKG, to measure electrical signals from your heart while you exercise, usually walking on a treadmill
• a stress echocardiogram, which includes an echocardiogram, a kind of cardiac imaging test, to take pictures of your heart before and after by walking on a treadmill or using a drug that takes the place exercise
• a nuclear stress test, which uses a small amount of radioactive material and a special camera to take pictures of your heart before and after by walking on a treadmill or in use of a drug that takes the place of the exercise

your doctor will decide what kind of test is best for you based on your symptoms and general health. Before your test, your doctor will tell you how to prepare, including what to wear and whether to take your regular medications.

Standard stress test exercise

Before the test, a nurse put sticky spots called "electrodes" on your chest, arms and legs. The nurse may have to shave your skin to ensure that the patches stick.

The electrodes connect to an electrocardiogram, which records the electrical activity of your heart. The nurse will place a blood pressure cuff on your arm to measure your blood pressure during the test.

During the test, you walk on a treadmill or pedal a stationary bike until your heart as hard as it can. The exercises will be more difficult during the test.

If you are not able to exercise, you will receive medicine to mimic the effects of exercise. This can cause chest pain, flushing, or other symptoms that disappear after the test is done

Be sure to tell the nurse symptoms you have, including :.

• Chest pain
• Breathlessness
• Vertigo

exercise stress echocardiography

is a stress echocardiogram similar to a standard stress test, but you echocardiogram or "echo" before and after exercise or take medications to work your heart stronger.

echocardiogram uses sound waves to take pictures of your heart in motion. During an echocardiogram, a specially trained technician presses a small device called a "sensor" against your chest and moves back and forth. The transducer detects and transmits sound waves, which are then read by the test monitor to show images of your heart.

nuclear stress test

A nuclear stress test uses a small amount of radioactive material and a special camera to take pictures of your heart before and after exercise or take medications to mimic the effects of exercise.

During the test, you get a shot of a harmless radioactive tracer and your heart is scanned as you rest. Then you are going to exercise or take medications to make your heart work harder and get another shot tracer and scanning.

A traditional nuclear stress test uses a gamma camera, a ring-shaped imaging machine to take pictures of your heart at rest and after activity. In a gamma camera, you must stand still with your arms above your head, and each test takes about 20 minutes.

Doctors of the Heart Institute and UPMC vascular also use the D-SPECT® newest nuclear cardiology camera that allows you to sit during the scans. This camera is available at UPMC Presbyterian.

Getting Results Stress Test

Your doctor will usually have the results of stress testing in about a week and review the results with you.

If your results are normal, you may not need further tests. If your results are abnormal, you may need other tests to find out what is causing your symptoms.

For more information on stress tests, contact the Heart and Vascular Institute at UPMC 1-855-UPMC- HVI (876-2484) .

Backlash welcomes the "bad luck" study of cancer and cover -

Digestive Health -

digestive health

The digestive system is one of the most important systems of our body. He is responsible for the distribution and transport of nutrients from the foods we eat and is also an important part of the immune system. Our digestive system consists of a long interconnected system organs ranging from the mouth to the anus. The key to a healthy immune system is a healthy digestive system and for this reason it is very important that we pay attention to the factors that affect our digestive system.

one of the most important factors in digestive health is the food we eat. Having a well balanced diet can make a huge difference to the health of our digestive system. Fiber, particularly insoluble fibers that are not absorbed by the body, allows the regularity maintaining the flow moving in the intestines. Soluble fiber breaks down into a gel and helps to absorb water and to slow digestion. Foods such as green vegetables, whole grains, beans and lentils are excellent sources of fiber. Women should consume at least 21-25 grams of fiber per day from a variety of food sources, while men should aim for 30-38 grams per day

fiber sources can be found in :.

• Grains - foods such as wheat, bran and brown rice are all sources of insoluble fiber that is on the outer shell of the plant. Oatmeal, barely and ground flaxseed are excellent sources of soluble fiber
• Vegetables -. Cellulose is a compound consisting of insoluble fiber found in certain vegetables such as carrots, cucumbers, celery and zucchini. Broccoli and Brussels sprouts are good sources of soluble fiber.
• Fruits - The outer skin of fruits such as apples, pears and tomatoes are good sources of insoluble fiber. Also the seeds of fruits such as blueberries, blackberries and cranberries are an excellent source of insoluble fiber. Fruits that contain soluble fiber include prunes, bananas and blackberries.
• Vegetable proteins - Legumes such as beans, lentils and peas are not only excellent sources of protein, but also provide an abundance of fiber insoluble. Nuts such as almonds and peanut skin contribute to the consumption of insoluble fiber. Seeds such as sunflower and pumpkin have a hard outer layer and fibrous. Black-eyed peas, chickpeas and beans are mainly composed of soluble fiber.

In addition to fiber, probiotics help support a healthy digestive and immune system. Probiotics are bacteria that help in the digestion process by maintaining a balance of healthy bacteria that break down and transport the food we eat natural

Probiotics Sources can be found at :.

• yogurts containing live cultures.
• Miso and tempeh, which are forms of fermented soybeans.
• aged cheeses like cheddar and blue cheese that are not cooked or processed.
• Sauerkraut is fermented cabbage is a great source of probiotics. Cabbage received probiotics during the fermentation process.

It is also very important to drink an adequate amount of water daily for good maintenance and health of our digestive system. The Centers for Disease Control and Prevention recommends drinking at least 64 ounces of water a day

Sources :. Centers for Disease Control and Prevention, American College of Sports Medicine, American Heart Association, LifeWork Strategies EAP, and Washington Adventist Hospital and Shady Grove. For more information, consult your doctor.

Heart-healthy recipes: Skillet Ham Hash Recipe -

Skillet Ham Hash is a tasty meal that is perfect for breakfast or brunch. We like this version of health heart, courtesy of the American Heart Association

How this recipe :.

Prep in a large nonstick skillet, heat oil over medium heat, stirring to coat the bottom. Cook the peppers and onion for four to five minutes, or until onion is tender and the pepper is tender, stirring occasionally.

Add the ham. Cook for one to two minutes, or until hot, stirring occasionally.

Stir fried potatoes and seasoning mix. Cook without stirring for four minutes, or until the bottom is golden brown. Stir (the brown gold coins will be distributed). Cook without stirring for four minutes, or until the bottom is golden brown and the mixture is heated through. Stir in parsley, salt and pepper.

Ingredients for Skillet Ham Hash

• Ingredients oil 2 teaspoons olive
• 1 large green pepper, diced
• 1 large red bell pepper, diced
• 1 medium onion, diced
• 1/2 cup diced lower sodium, low-fat ham (about 4 ounces), all visible fat discarded
• 3 cups nonfat frozen southern style hash brown diced potatoes, thawed
• 1/2 teaspoon salt without Cajun or Creole seasoning blend
• 2 tablespoons chopped fresh parsley soup
• 1/4 teaspoon salt
• 1/4 teaspoon pepper

Nutrition Facts

• Calories 205
• fat 3.5 grams
• saturated fat 0.5 g
• 0.5 grams polyunsaturated
• monounsaturated fat 2 grams
• cholesterol 12 milligrams
• sodium 421 milligrams
• Carbohydrates 36 grams
• fiber 5 grams
• Sugars 6 grams
• 9 grams protein

Learn more about eating healthy and taking care of your heart. Visit the website of the Heart Institute and UPMC vascular.

pacemaker could be hackable? -

NIH is rushing to pass a pediatric research windfall of $ 150 million -

The National Institutes of Health (NIH) is struggling this year to spend a windfall of more than $ 150 million pediatric research. And things could get a little hairy, judging by the reaction of an advisory group outside Friday for initial public release of the agency of his plans.

"Given the diffuse nature of what you have described, and its complexity, I don 't want to use the word" nuts ", but it is a challenge," Lila Gierasch of University of Massachusetts, Amherst, said the main NIH deputy director Lawrence Tabak after his presentation at a meeting of the Council recommendations in Bethesda, Maryland. "Thank you for changing nuts" to "difficult," said Tabak, tongue in cheek. "We just try to do what makes the most sense, and increase the potential value of the resources available to us."

The situation is certainly unusual for the agency's $ 30 billion, where a succession of flat budgets meant plunging the success rate of grant proposals. But NIH is only following the orders of Congress for two separate research initiatives to help children.

Last spring, lawmakers passed the law on research First Gabriella Miller children, allowing NIH to spend $ 126 million over 10 years for pediatric research. In December, they gave NIH his first $ 12.6 million. Taken together, authorization and ownership represented a kind of belt and suspenders approach to ensure that NIH follows the interest of legislators to have the agency do more to understand and find cures for any childhood cancer and juvenile arthritis teenagers suicide and obesity.

at the same time, the NIH has pulled the plug on the study of its National controversial for children (NCS), which was supposed to monitor various environmental and psychosocial factors affecting a cohort of 100,000 children from birth to 'so at 21, Congress directed NIH to find other uses for $ 165 million that lawmakers had already allocated in the final 2015 project spending bill for the massive study. Some money will go to the shutter existing activities and related study Vanguard, leaving about $ 140 million for new initiatives.

NIH officials have spent the last six weeks to react to this whirlwind of legislative activity and plot their next moves. Although the two pots of money are distinct, they hoped to use each of capitalizing on the eruption of new technologies that allow researchers to collect and analyze large amounts of information. On Friday, they presented their preliminary plans to the Board.

Kids First

The money for the Kids First initiative should help to enrich a number of studies of children already underway, said Elizabeth Wilder, head common Fund, which coordinates trans-NIH research programs. "The goal is to use information across cohorts to meet the compelling issues in pediatric research," she said to the council. "We want to develop a valuable resource for the pediatric community."

some board members were turned off, however, for such a generic description of the research plan. "I'm not as excited as I would be," said one. "I'm trying to imagine what I would do with that database." Another member of the Board characterized the NIH plan as "we have the ability of Big Data, so we'll apply it to children. "

Wilder admitted that the scope of the search to cover has not been determined." We do not have a Kids First definition of when childhood ends, "she said in response to a question whether studies of addiction and mental illness would be part of the initiative. (Miller, namesake of the law, died of cancer at the age of 10, and promoters the law systematically refer to it as support for research on pediatric cancer.) another board member asked whether studies on the results of the adults in these disorders are also fair game.

But the initial uncertainty has not bothered Marlene Belfort, a professor at the University of Albany, State University of New York. "I think there is more enthusiasm for this project I heard there 25 years ago, when we began to discuss the draft of the human genome, "she noted. "And look how much we have learned from that."

The pediatric research initiative as genome project, expected to be a multiyear effort. And the idea has won broad bipartisan support because it was presented as revenue neutral. Its funding comes to end federal aid for political conventions for the presidential candidate of each party, now funded by a $ 3 check-off on tax returns

Some $ 38 million of the electoral fund was set aside last spring at the initiative of the NIH, and representative Tom Cole (R-OK) has introduced a bill to transfer another $ 88 million in NIH completely eliminating the withholding tax mechanism, which also funds campaigns presidential. However, Congress funds federal agencies on an annual basis, so that the money for the first child should be appropriate each year.

study of manna children

However, the money for the study of the canceled child is a unique bargain. It must be spent, or at least initiated, before the year 2015 ends on 30 September. Congress also tied two ropes to money, Tabak told the Council: NIH must "remain faithful to the original intent of the study, to discuss issues at the intersection of pediatric health and environment, and we must also do a better job of engaging underrepresented communities. "

Moving quickly, a group of institute directors and senior NIH officials have concocted three options for spending the money NCS. As Tabak describes, the first would focus on development and employment new tools, such as biosensors to monitor the impact of environmental factors on pediatric diseases. the second would be to study the "seeds" of future diseases by factors affecting children before and after the birth of surveillance. the third would expand the existing studies to include more environmental factors. the goal, Tabak said, "is to develop tools and approaches that, if successful, could be applied to many studies of existing cohorts."

Tabak recognized the wave, which prompted the comment Gierasch on how much work needs to NIH in a very short time. But Tabak said NIH faces a challenge more great in 09 when Congress appropriated $ 10 billion to the body under the government stimulus plan in the wake of the financial crisis. "Do we have it so perfect? ​​Maybe not," he said. "But I think it worked pretty well in the end."

Several Board members suggested specific areas that NIH should take into account in any future solicitation NCS spend money, leading Tabak to warn that "we need to strike a balance between trying to be all things to all people and provide something useful. "He said the advantage of emphasizing the development of new tools is that" you can adapt "to all that the NIH studies decides to finance the road.

Tabak did not offer a timetable for decisions on how to distribute the money NCS. Wilder said she hoped the NIH leadership would decide "early spring" how the first year of Kids First funds would be spent.

Stroke - Every Second Counts, Do you know the signs -

Stroke - Every Second Counts, do you know the signs

Stroke is the fourth? leading cause of death and the leading cause of adult disability in the United States.

A blow cut the vital blood flow and oxygen to the brain. It occurs when a blood vessel to the brain is blocked by a clot or bursts. When this happens, part of the brain can not get the blood and oxygen it needs, it starts to die.

The treatment should begin as soon as possible after a stroke as possible for the best results. Every second counts, so it's important to know the signs. Call 9-1-1 immediately if you or someone you know shows any of these signs of a stroke:

• sudden numbness or weakness of face, arm or leg, especially on one side of the body
• sudden confusion, trouble speaking or understanding
• sudden trouble seeing in one or both eyes
• sudden trouble walking, dizziness, loss of balance or coordination
• Sudden, severe headache with no known cause

Shady Grove Adventist Hospital and Washington Adventist Hospital - both part of the Adventist healthCare system - recently received the stroke Gold Achievement Award over the quality of the American Heart Association (AHA) to our expert, high-quality stroke care. Our teams are on call 24 hours a day to help stroke patients and minimize long-term disability chances.

Of course, prevention is the best treatment. You can reduce your risk of stroke by:

• No Smoking
• Eating at least five servings of fruits and vegetables per day
• Avoid foods fat, cholesterol and salt
• Put on your walking shoes - try to get at least 30 minutes of activity on most days
• Keeping your blood pressure in check - talk Contact your doctor if you have high blood pressure as is the most controllable risk factor for stroke.

Heart-Healthy Recipes: Sweet potatoes and apples -

This tasty recipe, courtesy of the American Heart Association, can help to satisfy any sweet tooth dessert or breakfast

How sweet potatoes

Preheat oven to 350 ° F. lightly spray a glass pan 1 1/2-quart with cooking spray. In a small bowl, combine sugar and cinnamon. In the casserole, layer half each of the potatoes, sweet potatoes and cinnamon-sugar. Dot with approximately half of the margarine. Repeat. Bake, covered, for 1 hour to 1 hour 15 minutes, or until the sweet potatoes and apples are tender.

Ingredients

• spray kitchen
• 1/4 cup sugar
• 1/2 teaspoon cinnamon powder
• 3 medium sweet potatoes, peeled, cut crosswise into ¼ inch slices
• 2 medium sweet potatoes, such as Rome Beauty or Gala, peeled, each cut into 10 districts
• 3 tablespoons light tub margarine
• food exchanges: 1 starch, 1/2 fruit

Nutrition Facts

• Calories 101
• fat 2 grams
• 0 g saturated fat
• polyunsaturated 0.5 g
• monounsaturated 1 grams cholesterol 0 milligrams
• 61 mg of sodium
• Carbohydrates 21 g
• fiber 3 g
• sugars 14 g
• Protein 1 gram

more on healthy eating and taking care of your heart. Visit the website of the Heart Institute and UPMC vascular.