Gene therapy gets a high-stakes test

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Gene therapy gets a high-stakes test -

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a British team is designing a clinical trial even more radical than the prenatal stem cell therapy: the first test of gene therapy in pregnancy. Treatment aims to correct fetal growth retardation, in which blood flow to the placenta flexes. Gene therapy has had a checkered history in children and adults, with side effects, including cancer and at least one death. So instead of introducing new genes to the fetus itself, the team designed a blood gene promoting the flow of the uterine arteries.

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