UCLA
when they are older, lower patients develop syndrome a distinct form of dementia that mimics Alzheimer's disease. And of course, autopsies of patients with Down syndrome found proteins in their brains that build between nerve cells, called amyloid plaques and fibers twisted inside neurons, called tau tangles. Both are known physical manifestations of Alzheimer's disease that prevent neurons in the brain to function properly. When the researchers compared the levels of plaques and tangles in the brain healthy (center) with the young brains and middle-aged patients with Down syndrome dementia free (left) and with brain of Alzheimer's patients (right), they found such high levels of plaques and tangles in Alzheimer patients syndrome and down. But unlike Alzheimer's disease, the highest levels of amyloid and tau in the brain of Down syndrome were in the parietal and frontal regions of the brain, the team reports in the July issue of Archive of Neurology . These areas are associated not only with memory but with the behavior and reasoning. This could explain the change in the personality of a patient who arrived earlier in the Down dementia linked to Alzheimer's disease, the team said, offering researchers a new way to track dementia patients.
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