no link. A retrovirus found in cancerous prostate cells appears to play no rule in the CFS.
Robert Schlaberg and Harsh Thaker
a theory linking chronic fatigue syndrome (CFS) to Infectious mouse known as XMRV took a second big success. First proposed last October to Science , the connection CFS virus was quickly challenged by a British group. Now a second team of British virologists reports that, after the fabric 170 CFS examining patients, they failed to find evidence of XMRV
Patients with CFS often report that their state -. A mixture of symptoms, including unexplained pain and excessive fatigue - began after a viral infection otherwise normal. And scientists in the past have previously linked CFS to some viruses. However, these links have collapsed under surveillance and without a firm biological cause for CFS, victims continue to face skepticism that their state is a "real" disease.
National Institute Researchers from the UK for medical research was the last challenge to XMRV link, using PCR machines to drive the DNA of the mouse virus in human tissue . As they reported in February 15 Retrovirology , they found no trace of DNA in 299 samples taken from both CFS sufferers and patients healthy controls.
The team also looked at the blood serum of 565 people to see if they could identify the signs of an immune response to XMRV. In this approach, scientists have discovered antibodies that fight XMRV in 26 people. However, only one of these people CFS. The meaning is not clear, because the same antibodies can defend against other viruses related, and specific trigger in this case remains unknown. The main conclusion the authors draw is a company perhaps: "XMRV infection may occur in the general population, but with uncertain results now."
The work corroborates a study published in January by a team at University College London, the first to challenge the assumption of the mouse virus. The two teams met the work of a research group at the Whittemore Peterson Institute for Neuro-Immune Disease in Reno, Nevada, who reported finding XMRV in two thirds of 100 CFS patients. In independent studies, other researchers have established a link XMRV - again controversial - an aggressive form of prostate cancer.
The authors of the new offering some advice paper with their data: "Following the results reported here," they write, "it appears next prudent step for subsequent studies to compare samples and protocols between different laboratories around the world. "
This is a good idea, because the differences between laboratories are common, says David Griffiths, a virologist at the Institute Moredun in Midlothian, UK, who has studied the claim . for retrovirus as the cause of chronic diseases also notes that it can not find serious flaws with no published studies ". All those involved are doing things exactly as they should be" for the moment, then, the XMRV results remain hopelessly ambiguous. As Griffiths says, "There must be an explanation why the disparate results are emerging, but it may not be an easy thing to turn up."
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