In the latest twist in a controversial debate on a possible tie between a syndrome retrovirus and chronic fatigue (CFS), the review Retrovirology today published online a study led researchers from the Centers for Disease Control and Prevention (CDC) that refutes this link. The study, which took place in the publication because it conflicts with another pending study by US government scientists failed to find xenotropic virus-related murine leukemia virus (XMRV) in blood samples of 51 CFS patients and 56 healthy people.
This is the latest in a series of conflicting results. Last year, a team reported in Nevada Science an association between XMRV and CFS, a mysterious disease that has no known cause. Since then, three European studies have found no XMRV link, and now no CDC in American patients, either. But another team of US government: Researchers from the National Institutes of Health (NIH) and the Food and Drug Administration (FDA) has accepted a paper in Proceedings of the National Academy of Sciences ( PNAS ) confirming the connection. Government officials and PNAS and, until today, Retrovirology have held off published two new papers because of the discordant findings between US agencies.
CDC virologist William Switzer, senior author of Retrovirology paper says that after taking "a scientific break" and conferring with their colleagues from the NIH and FDA, the team of CDC concluded that nothing in their paper should be revised and that "we would go ahead" with the publication. the paper examines the possible reasons for discrepant results, such as differences in the way patients were recruited. ( the paper Science found them by doctors, while CDC recruited chronic fatigue group by telephone surveys in Georgia and Wichita, Kansas.)
More answers may come from a study organized by the National Heart NIH, Lung and Blood Institute to have several laboratories test the same set of clinical samples blind for XMRV. Four US and two outside laboratories government laboratories involved, including researchers from 'Whittemore Peterson Institute in Reno, Nevada, who wrote Science Document of last year. The test should be completed by the end of the year, says Switzer.
PNAS declined to comment on a request when the FDA-NIH paper will be published.
July 2nd UPDATE: The authors of PNAS paper decided it needs more work. Corresponding author Harvey Alter at the NIH Clinical Center, which is in Berlin this week, made the statement on June 30: "Our record has not yet been accepted for publication I and my colleagues are conducting additional experiments to ensure that data is correct. and complete. Our goal is not speed, but scientific accuracy. " Spokesman NIH John Burklow told Insider that the document had were accepted, but Alter and his co-authors decided to "pull back" and revise in response to questions raised by reviewers
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