hopeful.
tissue engineering bladders could be a good substitute for the real thing.
Wake Forest University
new bladders Doctors have successfully implanted grown from a patient's own cells in seven children and adolescents with congenital disease of the bladder. Laboratory grown bladders are the first internal organ tissue-engineered to work effectively in humans, and they represent an important step towards better treatments for many debilitating bladder disorder.
When our bladder works well, it expands like a balloon and, when full, the brain signals that we need to urinate. But in some patients with the disease of severe bladder, the bladder does not stretch enough or the brain does not receive the signal. This causes incontinence, bladder stones, and high pressure urine backups that can damage the kidneys.
For more than a century, urologists surgically fashioned replacement bladders for patients from pieces of their intestines, which are extensible and can form a bag. But they are a poor substitute because they secrete mucus that can block urination; they also subside waste that can cause kidney stones, bone problems, and cancer. Thus, over the years doctors have tried many other replacement tissues and synthetic materials, but none worked.
Anthony Atala, a urologist at Wake Forest University School of Medicine in Winston-Salem, North Carolina, and his colleagues developed a new approach. They took a biopsy size dime bladder tissue, which smooth muscle cells outside and the cells of the bladder-specialized lining inside. Then, they increased both types of cells in culture and superimpose them on a biodegradable scaffold in the shape of bladder. After more challenging, the bladders were surgically implanted in children with spina bifida had damaged neural connections that help of a full bladder signal.
grown in the laboratory bladders worked adequately in the first three patients, reducing incontinence and lowering the pressure slightly. But adequate was not good enough, then surgeons implanted bladder covered with a fabric called omenta nourishing as improving the blood supply to the bladder. In the three patients with these bladders, the bladder pressure was reduced by half, bladders held more urine, and incontinence was significantly reduced, the researchers report today The Lancet . Next year, the team plans to try Atala's bladders grown in the laboratory in adults with bladder problems of spinal cord. Later, they will use them to treat cancer of the bladder, Atala said.
"It is a fantastic job," said Steve Chung, urologist at Urology Advanced Institute of Illinois in Spring Valley. For now, he warns, laboratory grown bladders are proven only for patients with spina bladder lesions induced bifida, a relatively small group, "but I think in the very near future, we can l use for other diseases of the bladder. "
Related Sites
- Background on bladder disorders
- More on bladder disorders
- Page Home Wake Forest Institute for regenerative Medicine, with basic information on tissue engineering
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