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Summary
Since It was first described in 2012, the irisin hormone has raised hopes and controversy. In mice, the molecule seems to be released from muscles after exercise and circulate in the blood, promoting the production of brown fat burning energy cells. But as other labs have tried to develop the idea that irisin is a key regulator of metabolism and a potential drug target for metabolic diseases in humans, they obtained conflicting results. A new study sheds a tear in the irisin history by challenging the reliability of commonly used antibody-based test kits to detect the molecule. Its authors argue that most studies measuring irisin in human blood are not valid.
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